Table 5.
Main pharmacokinetic parameters of salsolinol, aconitine, paeoniflorin, and miltrione in CHF-HKYd rat serum ( ± SD, n = 6).
| Salsolinol | Aconitine | Paeoniflorin | Miltrione | |
|---|---|---|---|---|
| AUC(0−t) (ng/mL·h) | 2,327 ± 261.0 | 48.94 ± 16.43 | 2239 ± 177.8 | 1,098 ± 69.72 |
| AUC(0−∞) (ng/mL·h) | 2,344 ± 265.7 | 50.11 ± 16.01 | 2258 ± 178.8 | 1,125 ± 84.73 |
| T1/2 (h) | 3.271 ± 0.58 | 4.24 ± 1.83 | 3.223 ± 0.34 | 4.25 ± 0.82 |
| Tmax (h) | 1.25 ± 0.59 | 0.75 ± 0.00 | 6.00 ± 2.54 | 1.00 ± 0.00 |
| CL/F (L/h/kg) | 8.625 ± 0.96 | 424.7 ± 97.65 | 8.86 ± 5.55 | 17.87 ± 1.38 |
| V/F (L/kg) | 40.68 ± 9.03 | 2679 ± 1574 | 41.20 ± 0.83 | 108.7 ± 15.80 |
| Cmax (ng/mL) | 314.2 ± 36.84 | 8.96 ± 2.22 | 197.6 ± 27.66 | 178.9 ± 16.24 |