TABLE 1.
Characteristics of the included studies.
| Studies | Animals | Weight(g) | Animal model | Modeling method | Sample size | Interventions (SLBZS) | Intervention (model) | Time | Outcome |
|---|---|---|---|---|---|---|---|---|---|
| BDY2017 | Wistar rats | 180 ± 20 | UC | Lard (1. 6 g/kg, qod) + standing in 2 cm deep water (qd, 8 h/d) + fasting for 1 day (qod), 21d | 8/8 | △24 g/kg; □12 g/kg; ◇6 g/kg | DW | Qd, 21d | (9) (11) |
| CH2007 | Kunming mice | 20 ± 2 | SDDM | 100% Senna leaf decoction,0.5 ml, bid, 20d | 10/10 | 0.12 g/ml; 0.4–0.6 ml | NS | Qd, 10d | (1)(3)(4)(6)(7)(8) |
| CCH2004 | Kunming mice | 20 ± 1 | Chronic Diarrhoea | 100% raw rhubarb decoction, 0.5 ml, bid, 8d | 10/10 | 2.34 g/kg | NS | qd, 7d | (3)(4)(5) |
| DJL2011 | SD rats | 160 ± 20 | Delayed Diarrhoea | Caudal vein injection CPT-11,150 mg/kg/d, 2d | 8/8 | △8.2 g/kg; □5.58 g/kg; ◇3.51 g/kg | DW | qd, 10d | (2)(12)(14)(15) |
| DYW2007 | Wistar rats | 240 ± 30 | SDDM | 100% raw rhubarb decoction, 5 ml/100 g, 7d | 8/8 | 1.5 ml/100 g; Dc 0.108 g/ml | DW | qd, 14d | (8)(10) |
| FH2004 | SD rats | 300 ± 50 | UC | 0.1% 2,4-dinitrochlorobenzene 0.25 ml Enema +8% acetic acid enema 2 ml, 20 s | 9/10 | 0.9879 g/ml 3 ml | DW | qd, 15d | (12)(13)(14)(15) |
| HHR2008 | Kunming mice | 20 ± 2 | SDDM | 100% raw rhubarb decoction, 0.4 ml/20 g, qd, 8d | 15/15 | 4 ml/20 g; Dc 0.176 g/ml | NS | qd, 7d | (1)(3)(4)(5)(6)(7) |
| JYX2016 | Wistar rats | 160 ± 20 | UC | Lard (2 ml, qd) + standing in 2 cm deep water (qd, 8 h/d) + fasting for 1 day (qod), 21 d | 10/10 | △24 g/kg; □12 g/kg; ◇6 g/kg | DW | qd, 21d | (9)(11) |
| JMR2010 | Kunming mice | 20 ± 3 | SDDM | 100% Senna leaf decoction, 0.5 ml, bid, 20d | 10/10 | 0.12 g/m 0.5 ml | NS | bid, 10d | (1)(6)(7) |
| LJ2016 | Wistar rats | 85–95 | FD | High lactose feed + forced standing 10 h, 14d | 15/15 | △3.212 g/kg; □1.606 g/kg; ◇0.803 g/kg | NS | tid, 14d | -15 |
| LWX2015 | Kunming mice | 20 ± 2 | SDDM | 100% Senna leaf decoction, 0.5 ml, 10d | 10/10 | 0.02 ml/g | DW | qd, 7d | (2)(5) |
| LXB2014 | Kunming mice | 20 ± 2 | UC | TNBS/ethanol solution Enema (3 mg/ml, 40% ethanol) 0.1 ml, 1 min, qd | 10/10 | △560 g/kg; □280 g/kg; ◇140 g/kg | NS | qd, 10d | (9)(14)(15) |
| LY2017 | SD rats | 220 ± 10 | UC | 50%TNBS/ethanol solution (100 mg/kg), 0.8 ml, qd | 14/14 | △3 g/kg; □1.5 g/kg; ◇0.75 g/kg | NS | qd, 15d | (1)(12)(14)(15) |
| LZH2015 | Wistar rats | 200 ± 20 | UC | Lard (4 ml, qod) + Ice water gavage (2 ml, qod), 20d; 5%TNBS + 50%ethanol solution, 0.8 ml | 12/12 | 12 g/kg | NS | qd, 14d | (12)(13)(15) |
| LZH2020 | Wistar rats | 200 ± 20 | UC | Lard (4 ml, qod) + Ice water gavage (2 ml,qod),20d; 5%TNBS+50%ethanol solution, 0.8 ml | 12/12 | 15.6 g/kg | NS | qd, 14d | (12)(13)(15) |
| LHW2010 | Kunming mice | 20 ± 3 | SDDM | 100% Senna leaf decoction 0.5 ml, bid, 20d | 10/10 | 0.12 g/m 0.5 ml | NS | bid, 10d | (3)(4)(5) |
| SY2018 | Kunming mice | 20 ± 2 | SDDM | Kale and lard (1 ml/100 g, qod) + forced swimming, 14 d | 10/10 | 1.2 g/100 g | NS | bid, 14d | (1)(3)(4)(8)(10)(15) |
| SSZ2020 | C57BL/6 Mice | 18 ± 5 | SDDM | 100% Senna leaf decoction,0.2 ml/10 g, 14d | 10/10 | 0.2 ml/10 g; Dc 0.45 g/ml | DW | qd, 7d | (9)(15) |
| TJS2021 | SD rats | 225 ± 15 | UC | 5%TNBS 100 mg/kg + 50% ethanol 0.25 ml, once | 12/12 | △2.4 g/ml; □1.2 g/ml; Dc 10 ml/kg | DW | qd, 21d | (12)(14) |
| YY2019 | BALB/C Mice | 20 ± 2 | IBD | 5% DSS solution free drinking, 7d | 12/12 | △12 g/kg; □6 g/kg; ◇3 g/kg | — | qd, 15d | (13)(14) |
| YHQ2017 | Wistar rats | 180 ± 20 | CD | TNBS/ethanol solution (120 mg/kg), 1 min | 10/10 | 12 g/kg | NS | qd, 21d | (9)(11)(14) |
| YHQ2018 | Wistar rats | 180 ± 20 | UC | Disease + Symptoms | 10/10 | △24 g/kg; □12 g/kg; ◇6 g/kg | NS | qd, 21d | (12)(14) |
| ZJJ2019 | C57BL/6 Mice | 20 ± 2 | UC | 3% DSS solution free drinking, 7d | 10/10 | △31.2 g/kg; □15.6 g/kg; ◇7.8 g/kg | NS | qd, 14d | -9 |
| ZJL2010 | Kunming mice | 20 ± 3 | SDDM | 100% Senna leaf decoction 0.5 ml, bid, 20d | 10/10 | 0.12 g/ml | NS | bid, 10d | (1)(10) |
| ZYF2006 | BALB/C Mice | 21 ± 1 | colitis | 3% DSS solution free drinking, 7d | 10/10 | 31 g/kg | — | qd, 10d | (11)(14) |
| ZH2019 | SD rats | 180 ± 20 | UC | DSS solution free drinking (40 g/L) | 8/8 | 24 g/kg | NS | qd, 21d | (1)(12)(14)(15) |
Shenling Baizhu powder (SLBZS); ulcerative colitis (UC); spleen deficiency diarrhea model (SDDM); functional diarrhea (FD); inflammatory bowel disease (IBD); drug concentration (Dc); normal saline (NS); distilled water (DW); qd △SLBZS high -dose group; □SLBZS middle-dose group; ◇SLBZS low -dose group; body weight (1); diarrhoea score (2); spleen mass index (3); thymus index (4); phagocytosis of macrophages (5); red blood cell C3b receptor ring rate (6); red blood cell immune complex ring rate (7); secretory immunoglobulin A (8); interleukin (IL)-1β (9); IL-2 (10); IL-4 (11); IL-6 (12); IL-8 (13); IL-10 (14); tumour necrosis factor-α (15).