Table 1.

Summary table of data suggesting T-cell exhaustion in various IEIs.

Condition	Evaluation of exhaustion	References
APDS	Immune phenotype: ↑ PD-1, CD160, CD244 Function: ↓ cytotoxicity, IL-2, proliferation Other: ↑ apoptosis Rapamycin treatment: ↑ IL-2, proliferation PD-L1 blockade: ↑ cytokine, proliferation	Lucas et al. (2014) (53) Cannons et al. (2018) (56) Edwards et al. (2019) (57) Wentink et al. (2018) (59) Angulo et al. (2013) (101) Wentink et al. (2017) (102)
Trisomy 21	Immune phenotype: ↑ PD-1, CD160, CD244	Peeters et al. (2022) (103)
CARD11 GOF	Function: ↓ proliferation	Snow et al. (2012) (104)
DOCK8 deficiency	Immune phenotype: ↑ PD-1, CD244 Function: ↓ proliferation, cytokine (IL-2, TNF-α, and IFN-γ), cytotoxic molecules (CD107a, Granzyme A, and Granzyme B)	Pillay et al. (2019) (105) Randall et al. (2011) (106)
PDCD1 deficiency	Immune phenotype: ↑ TIGIT Function: ↓ cytokine (IFN-γ, TNF-α)	Ogishi et al. (2021) (74)
CVID	Immune phenotype: ↑ PD-1, TIGIT, CD244, LAG-3 Transcriptional and epigenetic factors: ↑ TOX, eomes Function: ± cytotoxic and proinflammatory molecules	Klocperk et al. (2022) (61)

APDS, activated phosphoinositide 3-kinase δ syndrome; CVID, common variable immunodeficiency; IEIs, inborn errors of immunity.

Upward arrow (↑) means upregulated/increased; Downward arrow (↓) means downregulate/decreased.