. 2022 Jul 31;107(10):e3990–e4003. doi: 10.1210/clinem/dgac459

Table 2.

TIR, TBR, and TAR of the whole patient population

Parameter	HbA1c < ₅₃ (n = 500)	HbA1c _53-63 (n = 386)	HbA1c _64-74 (n = 85)	HbA1c ≥ ₇₅ (n = 28)	P value
TIR^{3.9–10 mmol/L} (%)	90.5 (84.0-94.9)	78.1 (66.7-86.6)^a	55.0 (37.0-67.6)^a^,^b	27.2 (7.2-44.4)^a^,^b^,^c	<0.001
TBR^{< 3.9 mmol/L} (%)	0.65 (0.00-2.87)	0.00 (0.00-0.91)^a	0.00 (0.00-0.78)^a	0.00 (0.00-0.00)^a^,^b	<0.001
TBR^{< 3.0 mmol/L} (%)	0.00 (0.00-0.13)	0.00 (0.00-0.00)^a	0.00 (0.00-0.00)	0.00 (0.00-0.00)^a	<0.001
TAR^{> 10.0 mmol/L} (%)	5.79 (2.47-12.6)	20.1 (11.5-31.8)^a	44.1 (28.3-62.8)^a^,^b	72.7 (55.6-92.8)^a^,^b^,^c	<0.001
TAR^{> 13.9 mmol/L} (%)	0.00 (0.00-0.52)	1.17 (0.00-4.17)^a	8.98 (3.91-16.8)^a^,^b	23.7 (14.4-56.2)^a^,^b^,^c	<0.001
TIR^{3.9–10 mmol/L} (%), day	90.0(81.8-94.4)	74.5 (60.2-84.6)^a	46.4 (36.7-63.9)^a^,^b	25.3 (7.12-39.1)^a^,^b^,^c	<0.001
TBR^{< 3.9 mmol/L} (%), day	0.35 (0.00-2.43)	0.00 (0.00-0.52)^a	0.00 (0.00-0.17)^a	0.00 (0.00-0.00)^a^,^b	<0.001
TBR^{< 3.0 mmol/L} (%), day	0.00 (0.00-0.00)	0.00 (0.00-0.00)	0.00 (0.00-0.00)	0.00 (0.00-0.00)	0.026
TAR^{> 10.0 mmol/L} (%), day	7.29 (3.13-16.2)	24.1 (14.1-39.4)^a	53.3 (35.4-62.6)^a^,^b	74.7 (60.9-92.9)^a^,^b^,^c	<0.001
TAR^{> 13.9 mmol/L} (%), day	0.00 (0.00-0.69)	1.39 (0.00-5.38)^a	11.1 (4.49-21.4)^a^,^b	25.6 (14.6-58.0)^a^,^b^,^c	<0.001
TIR^{3.9–10 mmol/L} (%), night	97.4 (91.1-100.0)	94.0 (82.8-99.0)^a	74.0 (46.9-89.6)^a^,^b	29.7 (9.11-72.1)^a^,^b^,^c	<0.001
TBR^{< 3.9 mmol/L} (%), night	0.00 (0.00-4.69)	0.00 (0.00-1.04)^a	0.00 (0.00-1.04)^a	0.00 (0.00-0.00)^a^,^b^,^c	<0.001
TBR^{< 3.0 mmol/L} (%), night	0.00 (0.00-0.00)	0.00 (0.00-0.00)^a	0.00 (0.00-0.00)	0.00 (0.00-0.00)	0.005
TAR^{> 10.0 mmol/L} (%), night	0.00 (0.00-1.56)	3.13 (0.00-12.5)^a	18.75 (6.25-53.1)^a^,^b	70.31 (27.86-90.89)^a^,^b^,^c	<0.001
TAR^{> 13.9 mmol/L} (%), night	0.00 (0.00-0.00)	0.00 (0.00-0.00)^a	0.52 (0.00-6.77)^a^,^b	16.7 (2.60-47.4)^a^,^b^,^c	<0.001

Data are median (Q1-Q3). Differences between the 4 HbA1c groups were tested using the Kruskal-Wallis test with the post hoc Steel-Dwass test.

Abbreviations: TAR, time above range; TBR, time below range; TIR, time in range.

^a P < 0.05 vs. HbA1c < ₅₃.

^b P < 0.05 vs HbA1c _53-63.

^c P < 0.05 vs HbA1c _64-74.