Table 6.
Percentages of patients who failed to reach the TBR criteria
| Parameter | Subgroup | HbA1c < 53 | HbA1c 53-63 | HbA1c 64-74 | HbA1c ≥ 75 | P value |
|---|---|---|---|---|---|---|
| Age | Years | |||||
| TBR < 3.9 mmol/L (%) ≥ 4% | <65 | 42 (18.9) | 18 (11.9) | 6 (14.0) | 0 (0.0) | 0.070 |
| ≥65 | 66 (23.7) | 29 (12.3) | 5 (11.9) | 0 (0.0) | 0.002 | |
| TBR < 3.0 mmol/L (%) ≥ 1% | <65 | 16 (7.2) | 13 (8.6) | 4 (9.3) | 0 (0.0) | 0.673 |
| ≥65 | 22 (7.9) | 12 (5.1) | 4 (9.5) | 0 (0.0) | 0.433 | |
| Types of antidiabetic agents | Insulin and/or sulfonylureas | |||||
| TBR < 3.9 mmol/L (%) ≥ 4% | Yes | 34 (44.2)a | 34 (25.4)a | 10 (21.7)a | 0 (0.0) | <0.001 |
| No | 74 (17.5) | 13 (5.2) | 1 (2.6) | 0 (0.0) | <0.001 | |
| TBR < 3.0 mmol/L (%) ≥ 1% | Yes | 19 (24.7)a | 19 (14.2)a | 8 (17.4)a | 0 (0.0) | 0.043 |
| No | 19 (4.5) | 6 (2.4) | 0 (0.0) | 0 (0.0) | 0.409 | |
| Renal function | eGFR (mL/min/1.73 m2) | |||||
| TBR < 3.9 mmol/L (%) ≥ 4% | <60 | 37 (32.5)a | 16 (19.0)a | 4 (18.2) | 0 (0.0) | 0.059 |
| ≥60 | 71 (18.4) | 31 (10.3) | 7 (11.1) | 0 (0.0) | 0.003 | |
| TBR < 3.0 mmol/L (%) ≥ 1% | <60 | 12 (10.5) | 8 (9.5) | 3 (13.6) | 0 (0.0) | 0.889 |
| ≥60 | 26 (6.7) | 17 (5.6) | 5 (7.9) | 0 (0.0) | 0.642 |
Data are number of patients (%). Differences between the four HbA1c groups were tested with Fisher’s exact test. Differences between patients stratified by age, types of anti-diabetic agents, or renal function in each HbA1c category were tested with Fisher’s exact test.
Abbreviations: eGFR, estimated glomerular filtration rate; TAR, time above range; TBR, time below range; TIR, time in range.
a P < 0.05 between subgroups.