. 2022 Jul 31;107(10):e3990–e4003. doi: 10.1210/clinem/dgac459

Table 8.

TIR, TBR, and TAR during a 24-hour period, daytime, and nighttime in patients stratified by renal function

Parameter	eGFR (mL/min/1.73 m²)	HbA1c _< 53	HbA1c _53-63	HbA1c _64-74	HbA1c _≥ 75	P value
	<60 (n = 227)	n = 114	n = 84	n = 22	n = 7
	≥60 (n = 772)	n = 386	n = 302	n = 63	n = 21
TIR^{3.9–10 mmol/L} (%)	<60	90.3 (83.9-95.3)	75.3 (66.2-86.5)^a	54.3 (37.8-62.2)^a^,^b	36.6 (9.4-41.4)^a^,^b	<0.001
	≥60	90.8 (84.1-94.9)	79.2(67.2-86.7)^a	55.2(36.1-68.0)^a^,^b	27.2 (7.2-47.4)^a^,^b^,^c	<0.001
TBR^{< 3.9 mmol/L} (%)	<60	1.69 (0.00-6.12)^d	0.13 (0.00-1.89)^a	0.20 (0.00-2.73)	0.00 (0.00-0.00)^a	<0.001
	≥60	0.52 (0.00-2.47)	0.00 (0.00-0.78)^a	0.00 (0.00-0.65)^a	0.00 (0.00-0.00)^a	<0.001
TBR^{< 3.0 mmol/L} (%)	<60	0.00 (0.00-0.26)^d	0.00 (0.00-0.00)^d	0.00 (0.00-0.00)	0.00 (0.00-0.00)	0.080
	≥60	0.00 (0.00-0.00)	0.00 (0.00-0.00)^a	0.00 (0.00-0.00)	0.00 (0.00-0.00-)	0.004
TAR^{> 10.0 mmol/L} (%)	<60	4.69 (1.69-11.3)^d	23.6 (11.5-33.1)^a	42.7(36.1-61.6)^a^,^b	63.4 (58.6-90.6)^a^,^b	<0.001
	≥60	6.07 (2.73-12.9)	19.5 (11.5-31.8)^a	44.3 (28.0-63.9)^a^,^b	72.8 (52.6-92.8)^a^,^b^,^c	<0.001
TAR^{> 13.9 mmol/L} (%)	<60	0.00 (0.00-0.39)	1.30 (0.20-4.62)^a	12.6 (4.56-16.0)^a^,^b	19.7 (11.6-67.8)^a^,^b	<0.001
	≥60	0.00 (0.00-0.65)	1.11 (0.00-4.04)^a	8.59 (3.65-20.3)^a^,^b	24.9(17.3-52.3)^a^,^b^,^c	<0.001
TIR^{3.9–10 mmol/L} (%), day	<60	90.6 (81.4-95.4)	70.8 (58.4-83.7)^a	49.1 (36.7-57.5)^a^,^b	34.9(9.73-41.5)^a^,^b	<0.001
	≥60	89.9 (81.9-94.4)	75.0 (60.2-84.9)^a	46.2 (33.3-64.6)^a^,^b	23.6 (6.25-37.1)^a^,^b^,^c	<0.001
TBR^{< 3.9 mmol/L} (%), day	<60	0.87 (0.00-4.34)^d	0.00 (0.00-1.22)^a^,^d	0.09 (0.00-1.39)^d	0.00 (0.00-0.00)^a	<0.001
	≥60	0.35 (0.00-1.91)	0.00 (0.00-0.52)^a	0.00 (0.00-0.00)^a	0.00 (0.00-0.00)^a	<0.001
TBR^{< 3.0 mmol/L} (%), day	<60	0.00 (0.00-0.17)^d	0.00 (0.00-0.00)	0.00 (0.00-0.00)	0.00 (0.00-0.00)	0.236
	≥60	0.00 (0.00-0.00)	0.00 (0.00-0.00)	0.00 (0.00-0.00)	0.00 (0.00-0.00)	0.132
TAR^{> 10.0 mmol/L} (%), day	<60	6.16 (2.26-13.7)^d	27.8 (14.6-41.6)^a	50.7 (42.5-62.6)^a,^b	65.1 (58.5-90.3)^a,^b	<0.001
	≥60	7.81 (3.47-16.5)	23.7 (13.9-39.2)^a	53.8 (32.1-66.7)^a^,^b	76.4 (62.9-93.8)^a^,^b^,^c	<0.001
TAR^{> 13.9 mmol/L} (%), day	<60	0.00 (0.00-0.52)	1.57 (0.17-6.16)^a	12.9 (5.40-19.1)^a^,^b	19.8 (10.1-72.7)^a^,^b	<0.001
	≥60	0.00 (0.00-0.69)	1.39 (0.00-5.21)^a	10.94(4.34-21.9)^a^,^b	26.6 (20.0-54.0)^a^,^b^,^c	<0.001
TIR^{3.9–10 mmol/L} (%), night	<60	95.8 (87.0-100.0)^d	92.2 (80.5-99.0)	73.4 (34.4-83.3)^a^,^b	29.2 (8.33-78.1)^a^,^b	<0.001
	≥60	97.9 (91.7-100.0)	94.3 (83.3-99.0)^a	74.0 (46.9-90.6)^a^,^b	30.2 (9.90-66.2)^a^,^b^,^c	<0.001
TBR^{< 3.9 mmol/L} (%), night	<60	2.60 (0.00-10.4)^d	0.00 (0.00-1.04)^a	0.00 (0.00-9.38)	0.00 (0.00-0.00)^a	<0.001
	≥60	0.00 (0.00-2.60)	0.00 (0.00-0.52)^a	0.00 (0.00-0.52)^a	0.00 (0.00-0.00)^a	<0.001
TBR^{< 3.0 mmol/L} (%), night	<60	0.00 (0.00-0.00)	0.00 (0.00-0.00)	0.00 (0.00-0.00)	0.00 (0.00-0.00)	0.152
	≥60	0.00 (0.00-0.00)	0.00 (0.00-0.00)	0.00 (0.00-0.00)	0.00 (0.00-0.00)	0.035
TAR^{> 10.0 mmol/L} (%), night	<60	0.00 (0.00-0.52)	3.91 (0.00-13.0)^a	19.8 (4.69-33.3)^a^,^b	70.8 (21.9-91.7)^a^,^b	<0.001
	≥60	0.00 (0.00-1.56)	3.13 (0.00-12.5)^a	18.8 (6.25-53.1)^a^,^b	69.8 (33.9-90.1)^a^,^b^,^c	<0.001
TAR^{> 13.9 mmol/L} (%), night	<60	0.00 (0.00-0.00)	0.00 (0.00-0.00)^a	0.52 (0.00-14.1)^a^,^b	17.7 (2.60-53.1)^a^,^b	<0.001
	≥60	0.00 (0.00-0.00)	0.00 (0.00-0.00)^a	0.52 (0.00-6.77)^a^,^b	16.2 (2.60-47.4)^a^,^b^,^c	<0.001

Data are median (Q1-Q3). Differences between the 4 hemoglobin A1c groups were tested using the Kruskal-Wallis test with the post hoc Steel-Dwass test. Differences between patients stratified by renal function in each hemoglobin A1c category were tested with the Wilcoxon rank-sum test.

Abbreviations: eGFR, estimated glomerular filtration rate; TAR, time above range; TBR, time below range; TIR, time in range.

^a P < 0.05 vs. HbA1c < ₅₃.

^b P < 0.05 vs HbA1c _53-63.

^c P < 0.05 vs HbA1c _64-74.

^d P < 0.05 between subgroups.