Table 2.
Glucose, insulin, and glucagon response to meal tolerance test in adults with postbariatric surgery hypoglycemia
| Statistical test P values | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| RYGB (n = 20) | SG (n = 23) | HG vs non-HG | After SG vs RYGB | |||||||
| Characteristic | Non-HG n = 12 |
HG n = 8 |
Non-HG n = 14 |
HG n = 9 |
Overall | RYGB vs SG | RYGB | SG | Non-HG | HG |
| Fasting glucose, mg/dL | 91.2 (3.4) | 79.3 (2.8) | 84.1 (2.8) | 78.6 (1.9) | .03 | .23 | .09 | .50 | .47 | ≥ .999 |
| Peak glucose, mg/dL | 195.9 (10.2) | 174.1 (8.4) | 139.7 (9.3) | 126.2 (7.4) | < .001 | < .001 | .55 | .95 | .01 | .02 |
| Time to peak glucose, min | 38.8 (3.4) | 31.9 (3.4) | 28.9 (2.9) | 28.3 (3.0) | .10 | .04 | .51 | ≥ .999 | .18 | .86 |
| Nadir glucose (mg/dL) | 70.0 (2.5) | 46.1 (2.8) | 71.0 (1.5) | 51.4 (2.4) | < .001 | .51 | .001 | < .001 | .96 | .41 |
| Time to nadir glucose, min | 167.5 (18.3) | 108.8 (11.3) | 165.0 (15.0) | 136.7 (15.1) | .06 | .35 | .15 | .55 | ≥ .999 | .24 |
| AUCglucose(0-60 min) | 9273.1 (496) | 8058.8 (302) | 6986.8 (423) | 6509.2 (360) | .001 | < .001 | .39 | .92 | .02 | .07 |
| AUCglucose(0-240 min) | 26414.4 (1551) | 19875.0 (570) | 21564.6 (654) | 18765.8 (847) | < .001 | .03 | .007 | .07 | .04 | .66 |
| Fasting insulin, mU/L | 3.1 (0.7) | 3.2 (1.2) | 3.2 (0.6) | 2.8 (0.9) | .90 | .98 | ≥ .999 | .90 | .99 | .87 |
| Peak insulin, mU/L | 90.1 (15.1) | 171.0 (19.8) | 86.4 (16.6) | 90.3 (22.2) | .03 | .1 | .03 | ≥ .999 | .99 | .18 |
| Time to peak insulin, min | 40.0 (5.3) | 37.5 (4.0) | 43.9 (4.6) | 46.7 (4.6) | .44 | .15 | ≥ .999 | .88 | .89 | .50 |
| AUCinsulin(0-60 min) | 2825.2 (470) | 6145.2 (848) | 3209.0 (586) | 3105.8 (738) | .02 | .18 | .02 | .99 | .98 | .10 |
| AUCinsulin(0-240 min) | 5048.5 (804) | 7661.3 (962) | 5207.5 (847) | 5146.7 (1233) | .12 | .18 | .16 | .98 | ≥ .999 | .31 |
| Fasting glucagon, ng/L | 40.5 (2.2) | 47.5 (5.0) | 38.1 (2.3) | 37.6 (2.9) | .23 | .06 | .83 | .99 | .80 | .31 |
| Peak glucagon, ng/L | 64.8 (3.8) | 77.0 (4.6) | 57.7 (6.3) | 49.1 (2.3) | < .001 | < .001 | .29 | .74 | .15 | .004 |
| Time to peak glucagon, min | 37.5 (3.5) | 46.9 (14.0) | 33.2 (5.7) | 58.3 (8.5) | .08 | .85 | .99 | .07 | .58 | .64 |
| AUCglucagon(0-60 min) | 3259.2 (164) | 3827.5 (215) | 2893.4 (259) | 2470.8 (138) | < .001 | < .001 | .25 | .63 | .19 | .006 |
| AUCglucagon(0-240 min) | 12166.6 (529) | 14426.3 (862) | 10553.9 (505) | 10032.7 (506) | .001 | < .001 | .13 | .92 | .19 | .008 |
Data are presented as mean ± SEM unless otherwise specified.
Abbreviations: AUC, area under the curve; BMI, body mass index; HG, hypoglycemia; MTT, meal tolerance test; RYGB, Roux-en-Y gastric bypass; SG, sleeve gastrectomy.