Table 3.
Incretin hormonal response: glucagon-like peptide 1 and glucose-dependent insulinotropic polypeptide
| Statistical test P values | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| RYGB (n = 20) | SG (n = 23) | HG vs non-HG | After RYGB vs SG | |||||||
| Characteristic | Non-HG n = 12 |
HG n = 8 |
Non-HG n = 14 |
HG n = 9 |
Overall | RYGB vs SG | RYGB | SG | Non-HG | HG |
| Fasting GLP-1, pM | 9.3 (4.2) | 13.1 (4.6) | 6.8 (2.2) | 4.9 (0.6) | .85 | .47 | .98 | ≥ .999 | .95 | .87 |
| Peak GLP-1, pM | 31.7 (5.8) | 44.4 (7.2) | 16.9 (2.8) | 12.2 (1.8) | < .001 | < .001 | .48 | .49 | .09 | .007 |
| Time to peak GLP-1, min | 30.0 (3.2) | 28.1 (1.9) | 30.0 (2.7) | 25.0 (2.5) | .57 | .61 | ≥ .999 | .61 | ≥ .999 | .76 |
| AUCGLP-1(0-60 min) | 1327.5 (287) | 1853.5 (315) | 709.7 (147) | 538.1 (62.7) | .001 | < .001 | .48 | .91 | .09 | .01 |
| AUCGLP-1(0-240 min) | 3650.3 (1170) | 4883.5 (1156) | 2308.3 (731) | 1605.6 (121) | .02 | < .001 | .43 | .98 | .29 | .06 |
| Fasting GIP, pM | 46.7 (7.9) | 57.5 (7.7) | 48.0 (6.9) | 51.1 (9.2) | .58 | .85 | .39 | .99 | .99 | .91 |
| Peak GIP, pM | 392.3 (38.9) | 511.5 (98.1) | 517.8 (45.6) | 523.9 (63.6) | .28 | .11 | .83 | .99 | .25 | .99 |
| Time to peak GIP, min | 30.0 (3.7) | 28.1 (3.4) | 41.8 (4.5) | 50.0 (4.3) | .003 | < .001 | ≥ .999 | .33 | .15 | .02 |
| AUCGIP(0-6 min) | 16 386.6 (1867) | 21 772.5 (4033) | 21 251.0 (2100) | 20 822.5 (2676) | .43 | .29 | .75 | ≥ .999 | .35 | .99 |
| AUCGIP(0-24 min) | 36 920.8 (5115) | 44 553.1 (7813) | 53 546.7 (6124) | 50 390.9 (7684) | .21 | .06 | .93 | .98 | .15 | .96 |
Data are presented as mean ± SEM unless otherwise specified.
Abbreviations: AUC, area under the curve; GIP, glucose-dependent insulinotropic polypeptide; GLP-1, glucagon‐like peptide 1; HG, hypoglycemia; RYGB, Roux-en-Y gastric bypass; SG, sleeve gastrectomy.