Figure 5.
Results meta-analyses trimester 1. 1Defined as the weighted average change in reference limits across cohorts. 2Calculated using 2.5th to 97.5th percentiles, excluding prepregnancy thyroid disease, use of thyroid hormone–altering medication, and TPOAb positivity; the total number of participants in subgroups differs based on availability of data on additional exclusion criteria. 3Defined as prepregnancy diabetes mellitus. 4Defined as BMI > 30 kg/m2 at time of intake. 5Pregnancy by in vitro fertilization. 6Defined as gestational diabetes, gestational hypertension, pre-eclampsia, preterm birth, and/or small for gestational age.