Figure 6.
Results meta-analyses trimester 2. 1Defined as the weighted average change in reference limits across cohorts. 2Calculated using 2.5th to 97.5th percentiles, excluding pre-pregnancy thyroid disease, use of thyroid hormone altering medication, and TPOAb-positivity; the total number of participants in subgroups differs based on availability of data on additional exclusion criteria. 3Defined as prepregnancy diabetes mellitus. 4Defined as BMI >30 kg/m2 at time of intake. 5Pregnancy by in vitro fertilization. 6Defined as gestational diabetes, gestational hypertension, pre-eclampsia, preterm birth, and/or small for gestational age.