Table 1.

The major advantages and disadvantages of different BEVs isolation methods

Methods	Advantages	Disadvantages	References
Ultracentrifugation	Simple process; Great homogeneity; Lower costs.	Limited efficiency; Limited purity; Time-consuming.	39
Ultrafiltration	Simple process; Great homogeneity; High recovery rate.	Limited efficiency; Limited purity; Product loss.	55
Precipitation	Simple process; Lower costs; Suitable for large sample	Limited efficiency; Limited purity; Time-consuming.	56
Affinity isolation	High purity	High cost; Low availability.	56
Size exclusion chromatography	High purity; High biological properties	Time-consuming; Not suitable for large sample.	55
Density gradient centrifugation	High purity	High cost; Time-consuming.	40