Table 3.
Hematotoxicity, hepatotoxicity, and nephrotoxicity before and after therapy according to CTCAE 5.0
| Toxicity | CTC-grade | Baseline | 1st cycle | 2nd cycle | 3rd cycle | |||
|---|---|---|---|---|---|---|---|---|
| 2 weeks | 4 weeks | 2 weeks | 4 weeks | 2 weeks | 4 weeks | |||
| Leukopenia | Grade-1 | 4 | 3 | 2 | 3 | 6 | 3 | 2 |
| Grade-2 | 0 | 3 | 3 | 3 | 4 | 3 | 2 | |
| Grade-3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Grade-4 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Thrombocytopenia | Grade-1 | 0 | 3 | 3 | 1 | 3 | 1 | 3 |
| Grade-2 | 0 | 0 | 0 | 1 | 1 | 1 | 0 | |
| Grade-3 | 0 | 0 | 2 | 1 | 1 | 1 | 0 | |
| Grade-4 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Anemia | Grade-1 | 1 | 6 | 2 | 4 | 4 | 4 | 3 |
| Grade-2 | 2 | 0 | 2 | 1 | 1 | 0 | 1 | |
| Grade-3 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | |
| Grade-4 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Nephrotoxicity | Grade-1 | 6 | 1 | 2 | 1 | 1 | 1 | 0 |
| Grade-2 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Grade-3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Grade-4 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Hepatoxicity | Grade-1 | 3 | 1 | 3 | 2 | 1 | 1 | 0 |
| Grade-2 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Grade-3 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | |
| Grade-4 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |