Figure 2.

COL17 as a crucial regulator in wound repair. Several signalings (e.g., BP-IgG, EGFR and Wnt signaling) lead to increased COL17 expression, decreased COL17 proteolysis, and COL17 shedding. Then, up-regulation of COL17 regulates stem cell population dynamics and migration. For stem cell population dynamics, up-regulation of COL17 represents a higher level of cell quiescence and stemness, as well as inflammation and EMT. For stem cell migration, up-regulation and shedding of COL17 regulate migration velocity and directions through interactions with other intracellular or ECM components.