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. 2022 Sep 26;10(9):e004725. doi: 10.1136/jitc-2022-004725

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© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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cam1615TEM8 increases natural killer (NK) tumor infiltration and reduces endothelial density compared with functionally equivalent interleukin-15 (IL-15). A549 tumor was engrafted as outlined and mice were treated with NK cells and cam1615TEM8 or functionally equivalent IL-15. (A) Top: Representative anti-human Granzyme B stained tumor on day 23 at ×240 magnification. Bottom: The Granzyme B mask used for NK cell identification generated with QuPath Positive Cell Detection software. (B) Left: Dot plots of Granzyme B+ cell counts from seven frames in individual tumors. Right: Combined data for tumors from all mice. (C, D) Analogous data to A and B but with % anti-mouse CD31+ staining area at ×120 magnification on day 42 to evaluate endothelial density. ‘Fxn Eq. IL-15’ indicates ‘functionally equivalent IL-15’.