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. 2022 Sep 13;13:985405. doi: 10.3389/fimmu.2022.985405

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Copyright © 2022 Talukdar, Junecko, Lane, Maiello and Mattila

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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IFNλ1/3 expression in lung granulomas negatively correlates with bacterial burden. (A) IFNλ1/3 concentrations in non-diseased uninvolved lung (n=8) and lung granulomas (n=10) were normalized to total protein per sample and compared by ELISA. Bars represent median values. Statistical comparison by Mann-Whitney test for an unpaired comparison. (B) Correlation between log₁₀ transformed bacterial burden per granuloma and IFNλ1/3 concentration per granuloma. Pearson correlation coefficient and corresponding p-value reported and simple linear regression line shown.