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. 2022 Sep 24;22:18–33. doi: 10.1016/j.bioactmat.2022.09.015

Fig. 3.

Fig. 3

Characterization of PSC-laden collagen and Col/Fib hydrogels and transcriptomic comparison in human PDAC patients. A) Contraction of PSC-laden collagen and Col/Fib gels for a total duration of 7 days post-preparation standardized to the initial hydrogel size, n = 3. B) Gene expression analysis on 2D cultured PSCs treated with either vehicle (DPBS), 2 mg/mL fibrinogen or 1U/mL thrombin, n = 3. C) Gene expression analysis in 3D cultured PSC-laden collagen and Col/Fib gels, n = 3. D) Transcriptomic analysis in human cohort from public database GEO (GSE62165), 13 healthy vs. 118 PDAC patients. E) Correlation between the expression of ACTA2 and other genes found upregulated in patients. Mean + SEM, *p < 0.05, **p < 0.01, ***p < 0.001.