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. 2022 Sep 12;13:943812. doi: 10.3389/fphar.2022.943812

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Copyright © 2022 Dong, Yang, Zhang, Wang, Liu, Zhang and Fan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Apatinib accumulation in liver (A) and small intestine (B) at 0.25, 1, 4 h after intragastric administration presence or absence abdominal X-ray irradiation 45 mg/kg (Mean ± SD, n = 4). The t-test was used for data analysis between the two groups. ** significantly different from the absence X-ray irradiation group at p < 0.01, *** significantly different from the absence X-ray irradiation group at p < 0.001, **** significantly different from the absence X-ray irradiation group at p < 0.0001.