TABLE 2.

Pharmacokinetic parameters of apatinib (45 mg/kg, intragastrical administration) in rat plasma after abdominal X-ray irradiation (Mean ± SD, n = 3).

Parameter		0 Gy	0.5 Gy	2 Gy
T1/2	h	0.548 ± 0.162	0.776 ± 0.450	2.21 ± 2.18
Cmax	μg/mL	0.374 ± 0.0307	0.243 ± 0.101*	0.0833 ± 0.0171**
Tmax	h	1.67 ± 0.577	1.50 ± 0.866	2.00 ± 0.00
AUC0-t	μg·h/mL	1.32 ± 0.154	0.874 ± 0.391	0.313 ± 0.0129**
AUC0-∞	μg·h/mL	1.33 ± 0.154	0.878 ± 0.388	0.369 ± 0.0755**
Vd	L/kg	0.0267 ± 0.00584	0.0657 ± 0.0376	0.350 ± 0.286
CL	L/h/kg	0.0343 ± 0.00391	0.0600 ± 0.0306	0.125 ± 0.0245**
MRT	h	2.47 ± 0.372	2.71 ± 0.325	2.90 ± 1.09

T_1/2, Elimination half-life; C_max, The peak plasma concentration; T_max, Time to reach C_max; AUC_0-t, Area under the concentration-time curve from 0 to 12 h; AUC_0-∞, Area under the curve from 0 to infinity; Vd, Volume of distribution; CL, clearance; MRT, Mean residence time. * significantly different from the absence X-ray irradiation group at p < 0.05, ** significantly different from the absence X-ray irradiation group.