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. 2022 Sep 13;13:978840. doi: 10.3389/fgene.2022.978840

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Copyright © 2022 Wang, Jin, Liang, Zhang, Wu, Fan, Zeng and Deng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Identification of hsa-miR-21-5p as a potential upstream miRNA of PRKCE in KIRC. (A) The miRNA-PRKCE regulatory network. (B) The predicted miRNAs of PRKCE were analyzed by miRactDB. (C) Scatter plots and correlation analysis between hsa-miR-21-5p and PRKCE in KIRC. (D) The target bind site in the PRKCE 3′UTR was predicted by TargetScan. (E) The expression of hsa-miR-21-5p in KIRC and control normal samples was investigated by the starBase database. (F) TCGA database and statistical analyses of hsa-miR-21-5p expression in 71 pairs of KIRC tissues and adjacent normal tissues. (G–I) Survival curves of OS, DSS, and PFI between low and high expression of hsa-miR-21-5p in KIRC.