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. 2022 Sep 13;13:978840. doi: 10.3389/fgene.2022.978840

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Copyright © 2022 Wang, Jin, Liang, Zhang, Wu, Fan, Zeng and Deng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Chemokines mediated the regulatory effects of PRKCE on immune cell infiltration. (A) Proportions of the 24 tumor-infiltrating immune cell types in low and high expression groups of PRKCE. (B–E) PRKCE expression significantly negatively correlates with infiltrating levels of (B) Treg, (C) aDC, (D) Cytotoxic, and (E) CD8 T cells. (F–I) PRKCE expression significantly positively correlates with infiltrating levels of (F) Eosinophils, (G) Neutrophils, (H) Mast cells, and (I) T helper cells. (J–M) Pearson’s correlation analysis was applied to explore the relationships between the hsa-miRNA-21-5p/PRKCE axis and 4 Chemokines (CXCL13, CCL5, XCL2, and CCL4).