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. 2022 Sep 13;13:978840. doi: 10.3389/fgene.2022.978840

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Copyright © 2022 Wang, Jin, Liang, Zhang, Wu, Fan, Zeng and Deng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The relationship between PRKCE expression and immune checkpoint genes in KIRC. The expression of CD274 (PDL1), PDCD1 (PD1), CTLA-4, LAG3, PDCD1LG2 (PDL2), TIGIT, and HAVCR2 (TIM-3) in (A) pathologic stage I, II, III; (B) histologic grade G1, 2, 3, 4 and (C) M stage M0, M1. (D–G) PRKCE expression was negatively correlated with the checkpoint molecules in KIRC. Markers include PDCD1 (PD1), CTLA4, LAG3, and KLRB1. (H–K) The expression correlation of PRKCE with PDCD1, CTLA4, LAG3, and KLRB1 in KIRC was investigated by TIMER.