TABLE 7.
Authors | Year | Study Type | IPMN Cohort | No. of Cases | Definition of Margin Positivity | Margin Positive | Margin Positivity Risk Factor for Recurrence | Median Follow-Up |
---|---|---|---|---|---|---|---|---|
White et al14 | 2007 | SC | Noninvasive | 78 | Any grade of dysplasia; PanIN 3 (only) explicitly included | 29.5% (n = 23) | Yes | 40 months |
Park et al15 | 2011 | SC | Unselected | 103 | Any grade of dysplasia including invasive carcinoma | 4.9% (n = 5) | No | 26.7 months |
Mariya and Traverso16 | 2012 | SC | Unselected | 203 | Any grade of dysplasia including invasive carcinoma | 6.9% (n = 14) | No | 40 months |
He et al5 | 2013 | SC | Noninvasive | 130 | Not explicitly stated | 20% (n = 26) | No | 38 months |
Frankel et al9 | 2013 | SC | Noninvasive | 192 | Any grade of dysplasia; PanIN explicitly included | 45% (n = 86) | Yes | 46 months |
Kang et al17 | 2014 | SC | Unselected | 366 | Any grade of dysplasia | 17.8% (n = 65) | No | 44.4 months |
Marchegiani et al6 | 2015 | SC | Unselected | 381 | Any grade of dysplasia including invasive carcinoma | 15.5% (n = 59) | Yes | 58 months* |
Marchegiani et al18 | 2015 | SC | Main duct | 173 | High-grade dysplasia or invasive carcinoma only | 9.8% (n = 17) | Yes | 56 months* |
Yamaguchi et al19 | 2016 | SC | Unselected | 55 | Not explicitly stated | 29.1% (n = 16) | No | 2.3 years |
Dhar et al20 | 2018 | MC (8) | Noninvasive | 330 | Any grade of dysplasia; PanIN explicity included | 19.7% (n = 65) | No | 36 months |
Al Efishat et al22 | 2018 | SC | Noninvasive +microinvasive (≤10 mm of invasive component) | 319 | Any grade of dysplasia including invasive carcinoma; PanIN explicitly included | 50.8% (n = 162) | No | 42 months |
Hirono et al21 | 2020 | MC (11) | Unselected | 1074 | High-grade dysplasia or invasive IPMC; PanIN 3 (only) explicitly included | Not reported | No | 54.2 months |
Our study | 2020 | SC | Noninvasive | 126 | Any grade of dysplasia; PanIN explicitly included | 71.4% (n = 90) | No | 114 months |
MC indicates multicenter (number of institutions); SC, single-center.
Follow-up of survivors only.