. Author manuscript; available in PMC: 2022 Sep 28.

Published in final edited form as: Lancet Gastroenterol Hepatol. 2019 Oct;4(10):805–810. doi: 10.1016/S2468-1253(19)30175-X

Table:

Prospective analyses of the prevalence of alterations of HDR genes in pancreatic cancer

	Type of alterations	HDR genes	Number of patients	Prevalence

Lowery et al (2018)³⁵	Germline	BRCA1, BRCA2, CHEK2, ATM, RAD50, RECQL4, BLM, BRAD1, RAD51D, PALB2	615	12%
Pishvaian et al (2018)³⁶	Somatic	BRCA1, BRCA2, PALB2, ATM, FANCA, FANCC	640	14.9%
Johns Hopkins Hospital (unpublished)	Somatic	BRCA1, BRCA2, ATM, CHECK2, PALB2, FANCA, FANCD2, ATR	175	8.5 (36%^*)

HDR=homologous DNA repair.

Including all genetic alterations with significance to be determined.