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Precancerous neoplasia in the pancreas. (A) Low-grade PanINs involve the pancreatic ducts. They have apical mucin and mild cytologic atypia, with the nuclei still retaining their polarity. (B) High-grade PanIN shows increase architectural and cytologic atypia, which architectural complexity, nuclear pleomorphism, and loss of nuclear polarity. (C) Invasive PDAC shows severe architectural and cytologic atypia with a striking desmoplastic response in the stroma.
