Table 1.
Common factors secreted by mesenchymal stem cells[35]
|
Type
|
Representative factors
|
| Immunomodulatory factor | HGF, TGF-β1, PGE2, IDO |
| Chemokine | RANTES, SDF-1α, MIP-1α, MCP-1 |
| Nutritional factors | HGF, NGF, FGF-2, PDGF-AA, PDGF-BB, EGF |
| Haematopoietic growth factor | G-CSF, M-CSF, GM-CSF, EPO |
| Vascular regeneration factor | VEGF165, FGF-2, EGF, PDGF |
| Scar inhibiting factor | HGF, FGF-2 |
| Anti-apoptotic factor | VEGF165, FGF-2, HGF |
HGF: Hepatocyte growth factor; TGF-β: Transforming growth factor-β; PGE2: Prostaglandin E2; IDO: Indoleamine 2,3-dioxygenase; SDF-1α: Stromal cell-derived factor-1α; MCP-1: Monocyte chemoattractant protein-1; NGF: Nerve growth factor; FGF: Fibroblast growth factor; PDGF: Platelet-derived growth factor; G-CSF: Colony stimulating factor 3; M-CSF: Colony stimulating factor 1; GM-CSF: Colony stimulating factor 2; EPO: Erythropoietin; VEGF165: Vascular endothelial growth factor-165.