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. 2022 Sep 26;14(9):729–743. doi: 10.4252/wjsc.v14.i9.729

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©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.

This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

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Effects of mesenchymal stem cell treatment on biochemical indexes. A: Flowchart of rat treatment from day 0 to week 6; B: Fasting blood glucose and 24-h urinary albumin concentration; C: Concentrations of blood urea nitrogen and serum creatinine in rat serum; D: Relative mRNA expression of caspase 3, Bax, and B-cell lymphoma 2 (Bcl-2), and Bcl-2/Bax ratio in rat kidney tissues; E: Concentrations of glutathione peroxidase, malondialdehyde, and advanced glycation end products in rat kidney tissues; F: Levels of reactive oxygen species and superoxide dismutase in kidney tissues. Data are presented as the mean ± SD.^aP < 0.001 vs normal control group, ^bP < 0.01 vs normal control group, ^cP < 0.05 vs diabetic kidney disease group. NC: Normal control; FBG: Fasting blood glucose; 24 h U-Alb: 24-h urinary albumin; BUN: Blood urea nitrogen; Scr: Serum creatinine; Bcl-2: B-cell lymphoma 2; Bax: BCL2-Associated X; GPx: Glutathione peroxidase; AGEs: Advanced glycation end products; MDA: Malondialdehyde; SOD: Superoxide dismutase; NC: Normal control; DKD: Diabetic kidney disease; MSCs: Mesenchymal stem cells.