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. 2022 Sep 26;14(9):729–743. doi: 10.4252/wjsc.v14.i9.729

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©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.

This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

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TdT-mediated dUTP nick-end labeling and histopathology analysis of kidney tissues from all rats. A: TdT-mediated dUTP nick-end labeling staining. Nuclei: Blue; apoptosis: Green; B: Hematoxylin-eosin staining; C: Periodic acid-Schiff (PAS) staining; D: Mesangial index of PAS-positive areas in the glomerulus; E: Immunohistochemical staining of advanced glycation end products (AGEs); F: Integrated optical density of AGEs in kidney tissues. All scale bar: 50 μm. Data are presented as the mean ± SD.^aP < 0.001 vs normal control group, ^bP < 0.001 vs normal control group, ^cP < 0.05 vs diabetic kidney disease group. AGEs: Advanced glycation end products; NC: Normal control; DKD: Diabetic kidney disease; MSCs: Mesenchymal stem cells.