Table 4.

Multivariate analysis for postoperative CSF leakage.

Factors	OR	95% CI	P
Subarachnoid invasion	4.879	1.243–12.820	0.007
Suprasellar lesion	3.690	1.029–5.783	0.003
Intraoperative flow CSF leakage
Grade 1	2.387	1.085–4.783	0.128
Grade 2	5.442	1.781–14.021	0.111
Grade 3	7.392	2.458–19.736	0.012
Bony reconstruction	0.313	0.099–0.694	0.019

^aBold indicates significance.

CI, confidence interval; CSF, cerebrospinal fluid; OR, odds ratio.

Grade 1 = small “weeping” leak, without obvious or with only small diaphragmatic defect; grade 2 = obvious defect of sellar diaphragma or skull base dura mater with moderate CSF exudation; grade 3 = large CSF leak, large sellar diaphragmatic or skull base dural defect with extensive opening of suprasellar arachnoid cistern and/or opening of the floor of the third ventricle.