Table 2.

Receptors and ligands searched in PDSP and where necessary from other sources as specified.

Receptors*	Ligands where Ki for dopamine D2 receptor listed in PDSP	Ligands where alternative sources were required for Ki for dopamine D2 receptor
Dopamine D2 Serotonin 5-HT2A Serotonin 5-HT2C Alpha 2 adrenoceptor Histamine H1 Acetyl choline M1 Acetyl choline M4 *Dopamine D3 receptor was considered for cariprazine only	Amisulpride Aripiprazole Asenapine (listed as ORG-5222) Cariprazine Chlorpromazine Clozapine Droperidol† Flupenthixol, CIS Fluphenazine Haloperidol Iloperidone† Levomepromazine (methotrimeprazine) Loxapine Lurasidone (also listed as SM-13496) Olanzapine 9-OH-risperidone (Paliperidone) Perphenazine Pimozide Prochlorperazine Propericiazine (pericyazine) Quetiapine Risperidone Sertindole† Sulpiride Thioridazine† Trifluoperazine Ziprasidone	Blonanserin (Tenjin et al., 2013) Brexpiprazole (PDSP listed data for a ‘D2L’ receptor which was included in place of D2 after consulting the source (Maeda et al., 2014) Clopenthixol† (extrapolated from Christensen et al. (1984)) Pimavanserin (Kitten et al., 2018) Zuclopenthixol (Christensen et al., 1984)

^†For drugs of historical interest which are no longer available in most markets (clopenthixol, droperidol, iloperidone, sertindole and thioridazine) only dopamine D2 was searched.

PDSP: Psychoactive Drug Screening Project.