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. 2022 Aug 11;2(9):2001–2012. doi: 10.1021/jacsau.2c00281

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© 2022 The Authors. Published by American Chemical Society

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Rational selection of compact molecules that can modify the aggregation of Aβ with photoactivation. (a) Chemical structures and properties of 9,10-AQ (Parent); HQ, Ali, Qui, Pur (Group A); Dan, Rhe, Alo (Group B). 9,10-AQ, anthracene-9,10-dione; HQ, 1-hydroxyanthracene-9,10-dione; Ali (alizarin), 1,2-dihydroxyanthracene-9,10-dione; Qui (quinizarin), 1,4-dihydroxyanthracene-9,10-dione; Pur (purpurin), 1,2,4-trihydroxyanthracene-9,10-dione; Dan (dantron), 1,8-dihydroxyanthracene-9,10-dione; Rhe (rhein), 4,5-dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylic acid; Alo (aloe-emodin), 1,8-dihydroxy-3-(hydroxymethyl)anthracene-9,10-dione. (b) Sequence of Aβ. Hydrophobic residues are underlined. (c) Schematic description of the on-pathway aggregation of Aβ with the modulatory strategy employing the photoactivated AQ series.