Table 3. Multivariable analysis for progression-free survival.

HR, hazard ratio; CI, confidence interval; Ref, reference

*Analysis was done using a reference level of no hormonal therapy and no lung, liver, and brain metastases.

Variable	HR (95% CI)	p-value
Stage II (ref = stage I)	5.15 (1.00-26.52)	0.05
Stage III (ref = stage I)	35.90 (5.64-228.59)	<0.001
Stage IV (ref = stage I)	4,149.63 (139.71-123,249.44)	<0.001
*Hormonal therapy (ref = no)	0.27 (0.07-1.02)	0.054
*Lung metastasis (ref = no)	67.01 (16.65-269.63)	<0.001
*Liver metastasis (ref = no)	0.14 (0.03-0.70)	0.016
*Brain metastasis (ref = no)	12.28 (3.29-45.84)	<0.001