Week	Objective	Method
1–2	Adapt to the experience of fatigue during exercise.	Low-intensity adaptation (under 60% HR) [61]. Patients from group C (who did not meet the ACSM guidelines but have function > 50%) were recommended to increase physical activity, e.g., brisk walking at low intensity guided by BPE during pre-assessment. In patients from group B (low physical activity and functional status), training was gradually increased from 5 to 15 min. Intensity was modified based on PE.
2–14	Maintain constant intensity to achieve the prescribed aerobic HR thresholds based on an individualized test [62].	Patients were told to maintain both speed and BPE corresponding to a range between 60% and 80% of their maximum HR. Patients reduced intensity if they experienced any symptoms while exercising. Every two weeks, HR and BPE at a selected speed were measured in order to increase intensity in cases of improvement. In patients from group B, intensity was kept at 60% HR during 20 min during the first 3 weeks and increased to 60–80% maximum HR if tolerated.
12–14	Ensure learning and behavior change	These were the same methods as those of the neuromuscular adaptations.