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. 2022 Sep 28;22(5-6):294–302. doi: 10.1038/s41397-022-00289-1

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© The Author(s), under exclusive licence to Springer Nature Limited 2022, Springer Nature or its licensor holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

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Fig. 2 — A 3D visualization of a 2-layer network shows all the interactions retrieved from all sources described in the computational workflow (Fig. 1). DDIs are shown in the bottom layer with name annotations of COVID-19 treatments as the main nodes, whereas PPI interactions in the top layer with protein names. Drug-pharmacogene genes associations retrieved from PharmGKB are shown between layers.