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. 2022 Sep 28;22(5-6):294–302. doi: 10.1038/s41397-022-00289-1

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Fig. 3 — Nodes in circles are PGx genes significantly predicted to affect clinical outcomes. Black nodes in rhombus represent the diseases. Edges between a gene and disease show the associations according to GWAS and Kontou et al. predictions. The size of a node indicates the higher connectivity with diseases. The top highly connected nodes with degree greater than 4 are: HLA-DQA1: 16, APOE: 15, TOMM40: 11, CTLA4: 10, APOC1: 8, CYP2C19: 5, VEGFA: 4, CYP2C9: 4. The full list of gene-disease interactions is provided in Supplementary File 3.