Table 2.
Stratification genes by score and disease.
| COVID-19 treatments | Disease cluster | Genes involved in DDIs with score 1 | Genes involved in DDIs with score 2 | Genes involved in DDIs with score 3 |
|---|---|---|---|---|
| Adjunct therapies | 1 |
IRS1 ITGA2 ITGB3 NOS3 NTRK1 |
||
| 2 |
GPX1 B4GALT2 |
|||
| 3 |
CYP2C19 CYP2C9 CYP2D6 UGT1A6 |
CYP2C19 CYP2C9 CYP4F2 PTGS1 PEAR1 |
||
| 4 | NAT2 | NAT2 | ||
| Immunotherapies | 1 |
VEGFA CTLA4 |
||
| 2 | NR1I2 | NR1I2 | ||
| 3 | CYP3A4 |
CTP2D6 CYP3A4 UGT1A1 |
CYP2D6 UGTA1 |
|
| 4 |
ABCB1 TYMS VDR TYMSOS |
ABCB1 | ||
| Antiviral therapies | 1 |
HLA-DQA1 HLA-DRB1 MT-ND3 |
MT-ND3 | |
| 2 | NR1I2 |
NR1I2 APOE APOC1 APOC3 TOMM40 |
NR1I2 APOE APOC1 APOC3 TOMM40 SORCS2 |
|
| 3 |
CYP3A4 CYP2C19 CYP3A5 CYP2D6 UGT1A1 UGT1A3 ABCC2 SLCO1B1 |
CYP3A4 CYP2C19 CYP3A5 CYP2D6 UGT1A1 UGT1A3 ABCC2 SLCO1B1 G6PD UGT1A7 ENOSF1 SLC19A1 |
CYP3A4 CYP2C19 CYP3A5 CYP2D6 UGT1A1 UGT1A3 ABCC2 SLCO1B1 G6PD UGT1A7 |
|
| 4 |
ABCB1 ABCC1 |
ABCB1 ABCC1 TYMS TYMSOS MTR ZSCAN25 SLCO2B1 |
ABCB1 ABCC1 |
Genes are clustered in 4 disease groups. 1: Autoimmune, metabolic and neurological diseases, 2: Cardiovascular & other degenerativediseases, 3: Drug Metabolism and related blood disorders.