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. 2022 Sep 28;610(7931):394–401. doi: 10.1038/s41586-022-05271-2

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Fig. 2 — a, The RdRp domain is shown as cartoon, with the fingers subdomain in blue, the palm subdomain in red, the thumb subdomain in green, and the remaining NTD in orange. The active site is highlighted with a red asterisk. The partial supporting helix is observed in the fingers subdomain. b, The same view as in a, with catalytic motifs highlighted. c, The superposition of the RdRp domains of the EBOV (coloured by subdomains as in a) and VSV (grey) (Protein Data Bank (PDB) ID: 5A22) L proteins highlights the difference in the NTD. d, Close-up view of the specific insertion region of the EBOV L RdRp domain. e, Sequence alignment of the above specific insertion region spanning residues 190 to 225. The sequence is unique to filoviruses compared with other nsNSVs. MARV, Marburg virus; LLOV, Lloviu cuevavirus; RABV, rabies virus; RSV, respiratory syncytial virus.