Table 5.

Results of the SwissADME prediction.

	GI absorption	BBB permeant	Pgp substrate	CYP1A2 inhibitor	CYP2C19 inhibitor	CYP2C9 inhibitor	CYP2D6 inhibitor	CYP3A4 inhibitor	Lipinski #violations	Bioavailability Score	PAINS #alerts
5a	Low	No	No	No	Yes	Yes	Yes	Yes	2	0.17	0
5b	Low	No	No	No	Yes	Yes	No	Yes	2	0.17	0
5c	Low	No	No	No	Yes	Yes	Yes	Yes	2	0.17	0
5d	Low	No	Yes	No	Yes	Yes	Yes	Yes	2	0.17	0
5e	Low	No	No	No	Yes	Yes	Yes	Yes	2	0.17	0
5f	Low	No	Yes	No	Yes	Yes	Yes	Yes	2	0.17	0
6a	High	No	No	Yes	Yes	Yes	Yes	Yes	0	0.55	0
6b	High	No	No	Yes	Yes	Yes	Yes	Yes	0	0.55	0
6c	High	No	No	Yes	Yes	Yes	Yes	Yes	0	0.55	0
6d	Low	No	No	Yes	Yes	Yes	Yes	Yes	0	0.55	0
6e	High	No	No	Yes	Yes	Yes	Yes	Yes	0	0.55	0
6f	Low	No	No	Yes	Yes	Yes	Yes	Yes	0	0.55	0
Diflapolin	Low	No	No	Yes	Yes	Yes	Yes	Yes	1	0.55	0

(Continued)