Figure 2.
Antiviral response to SC35M and PR8 infection. Gene expression of IFNs and ISGs in SC35M- or PR8-infected (A) murine and (B) human lung tissues (105 PFU/mL, 48 hpi) were analyzed by qPCR and normalised to mock-infected samples. Bars represent fold change of relative expression levels ± SEM, dotted lines indicate no change in gene expression. Cytokine profile of infected (C) murine and (D) human lung tissues at 24 hpi. Scatter plots of individual murine lung tissue data with means ± SEM. N = 5 murine lungs/group, Kruskal Wallis followed by a Dunn’s post-test, * p < 0.1, ** p < 0.01, *** p < 0.001, **** p < 0.0001.