Figure 7.
SARS-CoV-2 infections of (A) hamster and (B) murine lung explants. Lungs were infected with 105 PFU/mL of the SARS-CoV-2 variant B1.531 for 72 h. Post-infection treatment with remdesivir [2 µM], or fluoxetine [20 µM] was initiated 2 hpi. Viral titres are expressed as PFU/per mL detected in the individual lung samples, with means ± SEM superimposed. (C) Antiviral gene expression was analyzed to assess the antiviral response in non-treated and treated SARS-CoV-2-infected murine lungs. Data were expressed as relative expression levels ± SEM relative to the two reference genes GAPDH and actin β. Symbols represent values of individual mice lungs, with the means ± SEM superimposed. Data were analyzed by Kruskal-Wallis test followed by a Dunn's multiple comparisons test, *p < 0.05, **p < 0.01, ***p < 0.001, n.d. non-detectable; n ≥ 5 murine lungs/group.