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SADS-CoV S cleavage by furin is not required for viral entry. (A) S proteins in pseudotyped viruses (pv) were examined by western blotting. BALD pv indicates pseudotyped viruses lacking S proteins. (B) Huh7 cells were transduced with the indicated pseudotyped viruses. After 48 h, viral entry was quantified by measuring luciferase levels. Statistical significance was assessed by Student’s t test. *P < 0.05; **P < 0.01; ***P < 0.001; ns, not significant.
