Table 1.
Inventory of compounds in cigarette smoke (CS) or heated tobacco product (HTP) emissions for which data are available for carcinogenicity classification, emissions, and inhalation unit risks.
| Compound | IARC Carcinogenicity Classification | Availability of Emissions Data (CS and HTP) | Availability of Carcinogenicity Data (Inhalation Unit Risk) |
|---|---|---|---|
| Acrylonitrile | 2B | √ | √ |
| Acetaldehyde * | 2B | √ | √ |
| 1,3-butadiene * | 1 | √ | √ |
| 3-monochloro-1,2-propanediol | 2B | √ (new) | √ (only oral) |
| Ethylene oxide | 1 | √ | √ |
| Formaldehyde * | 1 | √ | √ |
| 2-furanmethanol | 2B | √ (new) | √ |
| Furfural | 3 | √ (new) | √ (only oral) |
| Glycidol | 2A | √ (new) | √ (only oral or ip) |
| Benzo[a]pyrene * | 1 | √ | √ |
| Nitrobenzene | 2B | √ | √ |
| Propylene oxide | 2B | √ | √ |
| Allyl glycidyl ether | NC | √ | |
| Alpha-methyl styrene | 2B | √ | |
| 1,2-dibromo-3-chloropropane | 2B | √ | |
| 1,2-dibromoethane | 2A | √ | |
| Decalin | NC | √ | |
| Hydrazine | 2A | √ | |
| Isobutyl nitrite | 2B | √ | |
| Naphthalene | 2B | √ | |
| Propylene glycol mono-t-butyl ether | 2B | √ (new) | √ |
* World Health Organization (WHO) Study Group on Tobacco Product Regulation (WHO TobReg) list of nine priority compounds in emissions advised for mandated lowering [18]; CS, cigarette smoke; HTP, heated tobacco product; ip, intraperitoneal injection; NC, not classified by IARC; 1 is established carcinogen, 2A is probably carcinogenic, 2B is possibly carcinogenic by IARC, and 3 is unclassifiable according to IARC; (new) means that information on this compound became available after the publication of Slob et al. [12].