Table 2.
Sensitivity, specificity, and other diagnostic parameters of type-2 GIPL-1-based NGP29b, in the comparison of different TL clinical forms vs. endemic and nonendemic controls.
| Parameter | TL Clinical Forms vs. Endemic and Nonendemic Controls a | |||||
|---|---|---|---|---|---|---|
| TL (n = 80) | CL (n = 17) | ML (n = 16) | DL (n = 16) | SC (n = 31) | CD (n = 16) | |
| Original Values (%)b | ||||||
| Sensitivity | 95.0 | 82.4 | 93.8 | 100.0 | 100.0 | 93.8 |
| Specificity | 48.5 | 48.5 | 48.5 | 48.5 | 48.5 | 48.5 |
| FPR | 51.5 | 51.5 | 51.5 | 51.5 | 51.5 | 51.5 |
| PPV | 80.0 | 45.2 | 46.9 | 48.5 | 64.6 | 46.9 |
| NPV | 81.4 | 84.2 | 94.1 | 100.0 | 100.0 | 94.1 |
a
Controls: endemic (EC) (n = 15) plus healthy nonendemic controls (NEC) (n = 18) individuals.
b
Values calculated based on the initial cutoff value (Ci; titer = 1.000) (Figure 3A), as described in Material and Methods. Sensitivity = true positive (TP)/TP + false negative (FN). Specificity = true negative (TN)/TN + false positive (FP). False-positive rate (FPR) 100 − specificity. Positive predictive value (PPV) TP/TP + FP. Negative predictive value (NPV) TN/TN + FN.