Chart 2. Chart showing the scales used in MRI images.

Scale/Score	0	1	2	3	4
FAZEKAS White matter lesion Leukoaraiosis/ microangiopathy Fazekas et al. 24	No changes	Mild Scattered pointed foci	Moderate Initial confluence of foci	Severe Large, extensive and confluent areas	XXX
TMA Hippocampal atrophy Scheltens et al. 25	No changes no atrophy	Only enlargement of the choroid fissure	Also, enlargement of the lateral ventricle lateral horn	Moderate loss of hippocampal volume (height reduction)	Severe loss of hippocampal volume
GCA Global cortical atrophy Pasquier et al. 26	No changes no cortical atrophy	Mild sulci opening	Moderate Loss of gyri volume	Severe atrophy “knife blade”	XXX

TMA: temporal mesial atrophy; GCA: global cortical atrophy.