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. 2022 Sep 9;16:953991. doi: 10.3389/fncel.2022.953991

FIGURE 2.

FIGURE 2

Fibronectin type III domain containing protein 5 (FNDC5) mRNA expression inversely correlates with age and AD neuropathology. Z-scores for FNDC5 expression obtained from the RNA seq database of the Adult Changes in Thought (ACT) study (https://aging.brain-map.org/). (A) FNDC5 expression in postmortem hippocampal tissue from 77 to 89 years old and 90 + year-old subjects, N = 21 cases of 77–89 years old and 20 cases of 90 + years old. (B) Hippocampal FNDC5 z-scores across the CERAD scale for amyloid pathology. (N = 12 for CERAD 0, 11 for CERAD 1, 7 for CERAD 2, and 12 for CERAD 3). Correlations between hippocampal FNDC5 z-scores and brain Aβ42 (C) or Aβ42/Aβ40 ratio (N = 34) (D). (E) Hippocampal FNDC5 z-scores across the Braak scale for tau pathology. (N = 14 for Braak I-II and 25 for Braak III–VI). Correlations between hippocampal FNDC5 z-scores and brain AT8 (pSer202/Thr205 tau) (N = 38) (F) or pThr181 tau immunoreactivity (N = 34) (G). Statistics: two-tailed unpaired Student’s t-test (A,E) or unpaired one-way ANOVA with Sidak post-hoc test (B). Correlations (C,D,F,G) were determined using the Pearson method for parametric data or the Spearman method for non-parametric data.