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. 2022 Sep 24;17:4481–4496. doi: 10.2147/IJN.S378727

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© 2022 Wang et al.

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Moderate cardiac injury induced by CuO NPs in SHRs. Serum levels of some biochemical parameters related to inflammation, coagulation, cell junction and vasomotor were measured. (A) CRP. (B) TNF-α. (C) ICAM-1. (D) ET-1. (E) ACE. (F) vWF. * p < 0.05, ** p < 0.01 vs control at 24 h post-exposure. ^#p < 0.05, ^##p < 0.01 vs control at 72 h post-exposure. (G) H&E and (H) Masson’s trichrome stains of the myocardial injuries manifested with inflammation (blue color), coronary vein congestion and susceptible coagulation (yellow arrows), and fibrosis (blue color).