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. 2022 Sep 14;13:980435. doi: 10.3389/fimmu.2022.980435

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Copyright © 2022 Ji, Zhang, Cheng, Ge, Wang, Fang, Mucker, Chen, Ma, Zhang, Li, Hammond, Baracco, Holbrook, Frieman, Zhang, Wang, Hooper, Zhang and Zhu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Co-crystal structure of SARS-CoV-2-RBD/amubarvimab/romlusevimab. Amubarvimab and romlusevimab simultaneously bind to distinct, nonoverlapping epitopes on the RBD of spike protein. A side-view depiction shows cartoon representations of amubarvimab (magenta) and romlusevimab (red) together with RBD (cyan) in surface representation based on co-crystal structure of amubarvimab and romlusevimab Fabs with RBD. Romlusevimab epitope (red) and amubarvimab epitope (magenta) with mutation sites of impact on neutralization IC₅₀ over approximately 100-fold are marked in blue.