Table 1.

Treatment for non-small cell lung carcinoma (NSCLC) brain metastases (BM) with surgery and radiotherapy

Study, year	Design	Treatment	Local recurrence	OS	RN
Brown 2016 [26]	Prospective 213 pts	SRS (20–24 Gy) vs. SRS (18–22 Gy) + WBRT (30 Gy/12 fr)	HR 3.6	10.4 m 7.4 m p = NS
Prabhu 2017 [30]	Retrospective 213 pts	SRS 18 Gy S + SRS 15 Gy SRS + S 15 Gy	36% 20% p = 0.007	19.8% (2 y) 38,9% (2 y) p = 0.01	12.3% 22.3% p = 001 5%
Mahajan 2017 [4]	Prospective 132 pts	S S + SRS	67% 28% p = 0.015	18 m 17 m p = NS	None None
Prabhu 2019 [33]	Prospective/retrospective 147 pts	SRS 15 Gy + S	25.1%	17.2 m	0.8%

pts — patients; S — surgery; SRS — stereotactic radiosurgery; WBRT — whole brain radiotherapy; HR — hazard ratio; OS — overall survival; RN — radionecrosis; m — months