Figure 3:
Representative recordings of simultaneous measurement of CMG and EUS- EMG activity in a SCI rat (A1–A4) and an SCI mouse (B1–B4). Traces A2–A4 and B2–B4 are expanded from the traces A1 and B1, respectively, with different time scales. The SCI rat (A1–A4) exhibited EUS bursting with alternating APs and SPs during voiding bladder contractions, which coincided with rapid pressure oscillations in the CMG tracing. The SCI mouse (B1–B4) had intermittent voiding coinciding with more prolonged reductions in intravesical pressure in the CMG recording, which occurred during periods of low-tonic, synergic EUS-EMG activity (B3 and B4). Clear EUS bursting activity or intravesical pressure oscillations were not seen in the SCI mouse. #symbols in B3 and B4 indicate the reduced EUS activity (R-EA) during voiding.(Modified from Kadekawa et al., 2016[19]). CMG: Cystometrogram, EUS: External urethral sphincter, EMG: Electromyogram, SCI: Spinal cord-injured