Table 2.
Characteristics of included studies.
| Author -Year | Trial type | Simple size | Mean Age(Years) | Male ratio (%) | Intervention study(DEX dose/administration mode) | Neoplasm’s type | Comparators | Anesthesia method | |||
|---|---|---|---|---|---|---|---|---|---|---|---|
| CON | DEX | CON | DEX | CON | DEX | ||||||
| Mao Y-2020 (22) | RCT | 29 | 29 | 63.5 | 65.2 | 82.8 | 79.3 | Bolus (0.5 ug/kg) before induction, and then continuous infusion (0.2-0.4 ug/kg/h) during operation | Esophageal Cancer | Saline | I.V. |
| Dong W-2017 (23) | RCT | 37 | 37 | 38.7 | 36.3 | 54.1 | 62.2 | Bolus (1 ug/kg; 15 min) before induction, and then continuous infusion (0.2 ug/kg/h) during operation | Gastric Cancer | Saline | Combined |
| Niu Y-2022 | RCT | 30 | 30 | 69.0 | 68.0 | 60.0 | 56.7 | Bolus (0.6 ug/kg; 15 min) before induction, and then continuous infusion (0.2 ug/kg/h) during operation | Gastric Cancer | Saline | I.V. |
| Wang Z-2020 (17) | RCT | 50 | 60 | 68.3 | 68.4 | 60.0 | 63.3 | Bolus (0.5 ug/kg) before induction, and then continuous infusion (0.4 ug/kg/h) during operation | Gastric Cancer | Saline | Combined |
| Zhu Z-2017 (24) | RCT | 45 | 45 | 51.5 | 51.8 | 55.6 | 48.9 | Bolus (0.6 ug/kg) before induction | Gastric Cancer | Saline | Combined |
| Huai Q-2022 (25) | RCT | 40 | 40 | 63.5 | 61.7 | 65.0 | 60.0 | Bolus (0.5 ug/kg; 10 min) before induction, and then continuous infusion (0.4 ug/kg/h) during operation | Colon Cancer | Saline | Inhalation |
| Wang K-2018 (26) | RCT | 69 | 72 | 45.3 | 42.5 | 47.8 | 50.0 | Bolus (1 ug/kg; 10-15 min) before induction, and then continuous infusion (1 ug/kg/h) during operation | Colon Cancer | Saline | Combined |
| Zhao L-2020 (27) | RCT | 84 | 92 | 53.1 | 52.5 | 56.0 | 45.7 | Bolus (200ug) | Colon Cancer | Saline | I.V. |
| Ben Z-2016 (28) | RCT | 44 | 44 | 68.6 | 59.1 | Bolus (0.5 ug/kg) before induction, and then continuous infusion (0.1 ug/kg/h) during operation | Rectal Cancer | Saline | I.V. | ||
| Chen C-2016 (29) | RCT | 30 | 30 | 60.1 | 56.7 | 50.0 | 46.7 | Bolus (1 ug/kg; 10 min) before induction, and then continuous infusion (0.3 ug/kg/h) during operation | Colorectal Cancer | Saline | Inhalation |
| Kong Y-2021 (30) | RCT | 60 | 120 | 65.0 | 65.0 | NA | NA | Bolus (0.5 ug/kg) before induction, and then continuous infusion (0.4/0.8 ug/kg/h) during operation | Colorectal Cancer | Saline | I.V. |
| Liu X-2017 (31) | RCT | 48 | 48 | 69.1 | 68.4 | 54.2 | 52.1 | Bolus (1.5 ug/kg;30min) | Colorectal Cancer | Saline | I.V. |
| Liu Y-2020 (32) | RCT | 24 | 24 | 68.6 | 69.6 | 54.2 | 62.5 | Bolus (0.5 ug/kg; 15 min) before induction, and then continuous infusion (0.6 ug/kg/h) during operation | Colorectal Cancer | Saline | I.V. |
| Pan C-2016 (33) | RCT | 41 | 41 | 73.9 | 71.9 | NA | 48.8 | Bolus (0.5 ug/kg) before induction, and then continuous infusion (0.3 ug/kg/h) during operation | Colorectal Cancer | Saline | NA |
| Sun W-2021 (34) | RCT | 28 | 28 | 59.0 | 60.0 | 60.7 | 67.9 | Bolus (1 ug/kg; 10 min) before induction, and then continuous infusion (0.5 ug/kg/h) during operation | Colorectal Cancer | Saline | Combined |
| Zhang J-2019 (35) | RCT | 60 | 80 | 74.1 | 73.8 | 66.7 | 63.8 | Bolus (1 ug/kg; 15 min) before induction, and then continuous infusion (0.2-0.7 ug/kg/h) during operation | Colorectal Cancer | Saline | I.V. |
| Zhang Y-2014 (36) | RCT | 20 | 60 | 71.5 | 72.0 | 55.2 | 60.0 | Bolus (0.5 ug/kg; 15 min) before induction, and then continuous infusion (0.2/0.5/0.8 ug/kg/h) during operation | Colorectal Cancer | Saline | I.V. |