Figure 3.

Mechanisms of DMG targeting by immunovirotherapy. Oncolytic viruses (OV) are promising novel therapies for DMG as they can be delivered directly via intratumoral injection (a), bypassing the BBB. OV entry (b) and replication (c) within DMG cells induces direct oncolysis and release of new viral particles into the tumor bed, facilitating further inoculation and lysis of surrounding tumor cells (d). Tumor cell debris increases the exposure of the patient’s immune system to both existing and novel tumor antigens, bolstering immune-mediated anti-tumoral effects.